Riddles takes us to 1920s Boston, with gangsters and bootleg whiskey. And probably some deaths from natural causes. (If you insult a man called “Icepick”, I’d call that natural causes.)
https://www.drivethrurpg.com/en/product/362071/bootleg-whiskey-liquor-champagne-wine
Session 1: Check That Out, We’re Competent: The associates of Billy (“Icepick”) Grayson look into some bootleg liquor with… unusual properties.